Bloodstream infection is the most serious form of healthcare-associated infection and is associated with significant morbidity and mortality. Bloodstream infection continues to be severe, and often life-threatening, disease. Infective endocarditis due to nontuberculous mycobacteria (NTM) is a rare complication after heart valve surgery. The reported cases in the literature are associated with the insertion of biological and also of mechanical valves. Infective endocarditis is a form of endocarditis. It is an inflammation of the inner tissues of the heart, the endocardium, usually of the valves. It is caused by infectious agents, or pathogens, which are largely bacterial but a few other organisms can also be responsible.